Tzvia艾布拉姆森

Tzvia艾布拉姆森408-924-4872
tzvia.abramson@yihetianquan.com
DH 446

Education

  • 博士后:在博士. David Relman lab - Department of Microbiology and Immunology Stanford University
  • Ph.D/B.S. -师承教授. 约西·列维教授. Yoav Sharoni-医学部 以色列本古里安大学科学系.

课程

  • BIO 141L - Laboratory of pathogenic microbiology
  • BIO 142L - Laboratory of pathogenic microbiology
  • MICRO 20 - Lecture and laboratory - General microbiology
  • BIO 233 -免疫学技术
  • 基础免疫学-讲座
  • BIO 107L -基础免疫学-实验室
  • BIO 255 -免疫学杂志俱乐部

研究兴趣

It is intriguing how despite common microbial recognition motives, some microbes are able to reside within our organs, evading detection by the immune system, others trigger a strong immune response that may harm both the microbe and the host and yet others, can be tolerated by the immune system such that they thrive in our body while causing 慢性疾病. The organs exposed to the external environment are lined with mucosal tissue and are constantly in direct contact with microbes. 粘膜由专门的 network of immune and residential cells that together sustain the mucosal immunity. Immune cells use specific pattern of cell surface molecules that guide their migration from the blood or lymph nodes to a target organ (trafficking/homing molecules). In my research lab, we are currently study several aspects of the involvement of trafficking molecules in prolonged infections and 慢性疾病s:

  1. 百日咳博德特氏菌 induces an acute, highly contagious respiratory disease in humans, which is manifested 大量的循环免疫细胞. 然而，尽管有免疫反应， the clearance of the pathogen and the resolution of the symptoms are prolonged rather 类似于慢性疾病的. 在这个项目中，我们推测细菌 components reduce the levels of surface trafficking molecules on immune cells, thereby inhibiting the homing of immune cells to the respiratory mucosa and clear the infection. The outcome of this project may implicate the content of the acellular vaccine currently used to immunize human against pertussis infections.
  2. 炎症性肠病 (IBD) comprise several intestinal inflammatory conditions including Crohn’s Disease and 溃疡性结肠炎 that affect 50-100 per 100,000 of 加州的人口. Abnormalities of the immune system are especially implicated 在这些疾病中. The immature form of antibody producing cells are called plasmablasts, and those that migrate to the gut express a cell surface trafficking molecule termed alpha4beta7. The goal of this project is to understand the effect of commonly used therapies in IBD on the level of plasmablasts and how these changes relate to the response to therapy can be used to monitor the pace of the diseased.
  3. A newly initiated project will explore the manipulation and up-regulation of trafficking molecules expressed on immunosuppressive mesenchymal stem cells and their ability to migrate to brain tissue and reduce the inflammatory and destructive responses in 多发性硬化症小鼠模型.

* Students with research interests in these fields are encouraged to contact me to 进一步讨论可用的具体项目.

Publications

  1. Nguyen TM, Ravindra D, Kwong B, Waheed S, Ferguson R, Nicole Tarlton, Victoria Wu, 克里斯托弗年代. 塞奎拉，玛蒂娜·布雷默和 Tzvia艾布拉姆森  (2012) Differential Expression of Alpha 4 Integrins on Effector Memory T Helper 博德泰拉感染期间的细胞. 百日咳杆菌的延迟反应. PLoS 一个7 (12):e52903. doi:10.1371/journal.pone.0052903
  2. Nicole J Tarlton, Caroline M Green, Nicole H Lazarus, Lusijah Rott, Anthony P Wong, Oren Abramson, Martina Bremer, Eugene C Butcher and Tzvia艾布拉姆森. Plasmablast Frequency and Trafficking Receptor Expression are Altered in Pediatric 溃疡性结肠炎 炎症性肠病. 2012 Apr 5. doi: 10.1002/ibd.
  3. Abramson T， Kedem H, Relman DA 2008 Modulation of the NF-κB Pathway by 百日咳博德特氏菌 丝状血凝素. PLoS ONE3(11): e3825 doi: 10.1371/journal.pone.0003825
  4. Abramson T， Kedem H, Relman DA.” Differing modes of NF-kappaB activation by 百日咳博德特氏菌 巨噬细胞中的丝状血凝素 FOCIS2007年，加州圣地亚哥.
  5. Abramson T， Kedem H, Relman DA.” Differing modes of NF-kappaB activation by 百日咳博德特氏菌 巨噬细胞中的丝状血凝素 ASM2002 Los Angeles CA.
  6. Abramson T., Kedem H. 和Relman DA. Proinflammatory and proapoptotic activities associated with 百日咳博德特氏菌 丝状血凝素. I感染与免疫, 69 (4) 2650-2658 (2001).
  7. Abramson T， Kedem H, Relman DA.” 百日咳博德特氏菌 (Bp) filamentous hemagglutinin (FHA) has proinflammatory pro-apoptotic activities” ASM2000.
  8. Abramson T， Kedem H, Relman DA. “百日咳博德特氏菌 FHA (Bp-FHA) has a Direct Inflammatory and Cytotoxic Effect on the U-937 Monocytic Cell Line”. ICCAC1999.
  9. Sion-Vardi N., Kaneti J., Segal-Abramson T., Giat J., Levy J. 和夏洛妮Y. GnRH specific binding sites in normal and malignant 肾组织”. 泌尿外科杂志 148(5):1568-70 (1992).
  10. Abramson-Segal T.Kitroser H., Levy J., Shally AV. 和夏洛妮Y. LHRH激动剂的直接作用 and antagonists on MCF-7 mammary cancer cells. Proc. Natl.Acad. Sci.美国15,89 (6):2336 - 9. (1992).
  11. Abramson-Segal T., Levy J., Giat J. 和夏洛妮Y. Guanine nucleotide modulation of high affinity 乳腺肿瘤中的GnRH受体. Molec. Cell. Endocrinol. 85:109-106 (1992).
  12. Segal T., Levy J. 和夏洛妮Y. GnRH analogs stimulate Phospholipase-C activity in mammary 肿瘤膜:GTP的调节. Molec. Cell. Endocrinol. 53: 239-243 (1987).